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KMID : 0525720140190030165
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Journal of Chitin and Chitosan
2014 Volume.19 No. 3 p.165 ~ p.173
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Anti-inflammatory Potential of Chitin, Chitosan and Chitooligosaccharides: A Review
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Lodhi Gaurav
Kim Yon-Suk
Hwang Jin-Woo
Kim Se-Kwon
Jeon You-Jin
Moon Sang-Ho
Jeon Byong-Tae
Park Pyo-Jam
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Abstract
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Inflammation is primarily a defense mechanism of the host against invading pathogens with the main purpose being mainte-nance of tissue homeostasis. However, if it goes uncontrolled or unchecked, it leads to a plethora of pathological conditions including tissue damage, tumorogenesis and even organ failure. Chitin is a non-toxic, natural biopolymer synthesized in enor-mous amount by living organism. Chitosan is a partially deacetylated derivative of chitin. Both chitin and chitosan have been in the center of research because of their functional properties but poor solubility limits their application. Chitooligosaccharides(COS) are chemically or enzymatically degraded products of chitosan or chitin with an advantage of increased solubility. The application of chitin, chitosan and COS varies from being used in food, cosmetics, biomedicine, agriculture, environmental protection, and waste water management to being used as a bioactive material and carriers in drug delivery. In light of the various proven biomedical applications of chitin, chitosan and COS, this review focuses on their anti-inflammatory potential.
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KEYWORD
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Anti-inflammatory, Chitin, Chitosan, Chitooligosaccharides
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